Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins
نویسندگان
چکیده
منابع مشابه
Rab10 in insulin-stimulated GLUT4 translocation.
In fat and muscle cells, insulin stimulates the movement to and fusion of intracellular vesicles containing GLUT4 with the plasma membrane, a process referred to as GLUT4 translocation. Previous studies have indicated that Akt [also known as PKB (protein kinase B)] phosphorylation of AS160, a GAP (GTPase-activating protein) for Rabs, is required for GLUT4 translocation. The results suggest that...
متن کاملSustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity.
Hyperglycemia and hyperinsulinemia are cardinal features of acquired insulin resistance. In adipose cell cultures, high glucose and insulin cause insulin resistance of glucose uptake, but because of altered GLUT4 expression and contribution of GLUT1 to glucose uptake, the basis of insulin resistance could not be ascertained. Here we show that GLUT4 determines glucose uptake in L6 myotubes stabl...
متن کاملInsulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
Insulin-stimulated translocation of the glucose transporter GLUT4 to the cell surface in fat and muscle cells is the basis for insulin-stimulated glucose transport. Studies in adipocytes strongly support the following molecular mechanism for this process. Insulin-elicited phosphorylation of the GTPase-activating protein TBC1D4 (AS160) suppresses its activity toward Rab10 and thereby leads to an...
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T2DM is primarily linked to obesity and insulin resistance—a decreased sensitivity of glucose response to normal insulin levels—which have been linked to defects in the insulin signaling pathway. Analysis of detailed mathematical models of insulin signaling should yield a better understanding of the underlying mechanisms of insulin resistance and its subsequent progression to T2DM. This may be ...
متن کاملInsulin-stimulated Translocation of Glucose Transport
A specific D-glucose-inhibitable [3H]cytochalasin Bbinding assay is used to examine the time course, reversibility, and hormone concentration dependency of an insulin-induced translocation of glucose transport systems from a large intracellular pool, associated with a low density subfraction of the microsomal membranes, to the plasma membrane in isolated rat adipose cells. The number of glucose...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.26.15169